Breast Cancer Essay Research Paper Genetic Testing free essay sample

Breast Cancer Essay, Research Paper Familial Testing for Breast Cancer Breast Cancer touches each of our lives in someway. Almost everyone knows person who has been touched by it, and many of us live in fright of what it will make to us personally. Breast malignant neoplastic disease has been around of all time since I can retrieve ; it has affected my grandma and my female parent. Unfortunately my female parent was non able to contend this awful disease and died when I was merely 16. These were really difficult times for me, and of all time since so, my life has neer been the same. I neer knew how painful this disease could be for the person every bit good as for the household, by conveying agony and opening lesions that neer heal. Harmonizing to the National Women Health Information Center, chest malignant neoplastic disease is the most normally diagnosed malignant neoplastic disease and the 2nd prima cause of malignant neoplastic disease decease in American adult females today. We will write a custom essay sample on Breast Cancer Essay Research Paper Genetic Testing or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page The Health Technology Advisory Committee, estimates that there will be approximately 175,000 new instances of invasive chest malignant neoplastic disease this twelvemonth among adult females in the United States and there will be an norm of 43,300 adult females deceasing from this disease yearly. Breast malignant neoplastic disease is the most common type of malignant neoplastic disease among adult females, with about one in nine adult females developing the disease in her life-time ( National Cancer society. ) Although chest malignant neoplastic disease is known to impact adult females, it besides can be every bit lay waste toing to work forces. Male chest malignant neoplastic disease histories for one per centum of all diagnosed malignant neoplastic disease. Breast Cancer is disease in which cancerous cells are found in the tissues of the chest. These cancerous cells continue to turn and finally organize into lumps known as a tumour. A tumour is a mass of new tissue growing that is unresponsive to normal controls of the organisation influence of next tissues ; has no utile physiological map ( Lexicon Universal Encyclopedia 19:330 ) . The are two sort of tumours found in a adult females chest ; a benign and a malignant tumour. A benign tumour by and large grows easy and does non distribute to any portion of the organic structure. On the other manus, a malignant tumour is really unsafe. This tumour kills unless treated, because of its invasive and metastatic features. Every adult female is at hazard of obtaining Breast Cancer, nevertheless, some are at higher hazard than others. Simply being a adult female is the chief hazard factor for developing chest malignant neoplastic disease. Breast malignant neoplastic disease can impact work forces, but this disease is about one hundred times more common among adult females. A adult females? s hazard of developing chest malignant neoplastic disease increases with age. About 77 per centum of adult females with chest malignant neoplastic disease are over age 50 at the clip of diagnosing. Womans aged between 20 and 39 history for merely zero three per centum of chest malignant neoplastic disease instances ( TNCI ) . A chart from the National Cancer Institute illustrated that a adult female by that age of 30 is one out of two thousand five 100s and 20 at hazard of obtaining chest malignant neoplastic disease. The chart besides illustrated that a adult female by the age of eight her hazards of obtaining chest malignant neoplastic disease addition by one out of 10. Research has showed that those adult females, who have a personal history of chest malignant neoplastic disease, are five to six times at greater hazard of acquiring the disease than those who don? Ts have a personal history ( Hirshuat 67 ) . Womans who got their menses before the age of 12 are besides at higher hazard of developing malignant neoplastic disease than those who got their menses after the age of 15. Louise Brinton, Ph.D. , head of the Environmental Studies Section at the National Cancer Institute stated that, ? Many misss who get their periods at an early age tend to be corpulent, which is a separate hazard factor later in life. ? ( qtd. Women Weigh the Pros and Cons of Genetic Testing for Breast Cancer ) . The mean age of climacteric in the United States is about 55. Womans who enter climacteric after the mean age are at twice the hazard of developing chest malignant neoplastic disease so adult females who enter climacteric before ago of 55. Never holding a kid or holding the first kid after age of 35 would besides increase their hazard of developing chest malignant neoplastic disease. Research workers from the National Cancer Society have stated that the usage of intoxicant is clearly proven to increasing hazard of developing chest malignant neoplastic disease. Compared with abstainers, adult females who consume one alcoholic drink a twenty-four hours have a really little addition in hazard. Those who have two to five drinks daily are about one and a half times higher in hazard than adult females who do non imbibe intoxicant. There are many ways to observe chest malignant neoplastic disease. The earliest chest malignant neoplastic diseases found the better the opportunities for successful intervention. Every adult female should follow these guidelines whether they have a household history of chest malignant neoplastic disease or non. Mammography is an X ray of the chest. This is used to happen the disease in adult females who have symptoms or do non hold any chest jobs. Every adult female who falls between the ages of 40 and 90 should take this trial yearly. The mammogram should be between 25 dollars and two hundred and 25 dollars, there are assorted organisations and adult females support groups across the state who provide referrals to low-cost or free mammography services. Clinical Breast Examinations is another manner to observe chest malignant neoplastic disease. In this test, the wellness professional examines the adult females? s chest for any alterations in form or size and so gently fells the che st. This test should be practiced every three old ages for adult females who are in the ages between 20 and thirty-nine. Another easy and cheap manner to observe chest malignant neoplastic disease is by making the chest introspection ( Library General Health Encyclopedia ) . BSE consist of analyzing the chest every month or a hebdomad after every menses period. All this methods are utile for observing chest malignant neoplastic disease before it becomes a tumour. Breakthrough in familial research have identified two cistrons which will convey hope to many adult females by conveying them consequences of life economy, early sensing and intervention. However, this trial has hazards and benefits. The thought that cistrons play a function in 1s hazard of obtaining chest malignant neoplastic disease is terrorizing. However, in fact, genetic sciences is one of the most exciting and advanced countries of research in chest malignant neoplastic disease today. This recent find brings hope to many adult females. Approximately 5-10 % of chest malignant neoplastic disease instances are caused by a known familial familial alteration ( Breast Cancer Genes: The BRCA1 and BRCA2 ) . The first cistron to be identified was the BRCA1, Breast Cancer Gene 1. BRCA1 was discovered in 1994 after 4 old ages of research by a squad lead by Dr. Mark Skolnick, Ph.D. , a genetic sciences and professor of the University of Utah Medical Center and Dr. Roger Wiseman of NIH ( Benjamin ) . The cistron is located in the long arm of the chromosome 17, one of the 23 braces of chromosomes found in the human cells ( BRCA1 Sequence Analysis ) . Sean V. Tavtigian stated in the article BRCA 1 cistrons and its Protein Products, that any adult females who has a household history of chest malignant neoplastic disease, has a even opportunity of inheriting a flowed transcript from either parent? ( qdt. BRCA1 Gena 18 ) . Dr. Mark Skolnick noted that the cistron? BRCA 1 is over 10 times larger than the mean cistron and could be prone to many types of mutant along its? span? ( qtd. in Baron-Faust 10 ) . A adult female who inherits a faulty transcript of BRCA 1 from her female parent or male parent besides has a normal transcript of the BRCA1 on most of the instances. Equally long as one normal transcript is present, her chest malignant neoplastic disease cells function usually. However, at some clip during her life, she is really likely to endure a mutant to the staying normal cistron transcript in one or more breast cells. The rate for these cells to develop into chest malignant neoplastic disease is highly high. Harmonizing to the Policy Statement of Genetic Testing for Breast Cancer, every bit many as 90 per centum of these adult females will develop it than a adult females with? normal? cistrons. A 2nd of import cistron act uponing chest malignant neoplastic disease today is BRCA2, chest malignant neoplastic disease cistron 2. This cistron was identified in 1995 by Dr. Douglas Easton of London? s Institute of Cancer Research ( Benjamin ) . The cistron is located in the long arm of chromosome 13. Another major familial defect associated with BRAC2 a tumour suppresser cistron called p53 located on the short arm of chromosome 17 ( Baron-Faust 58 ) . The? P? is used as an abbreviation for stating that is in the smallest portion of the chromosome 17. Another jobs in the cistron p53 will interfere with the production of a protein is what keeps that cells growing under control. Defects in p53 are believed to be among the most common familial defect in chest malignant neoplastic disease. A individual can be born with a faulty cistron or the cistron can go damaged thought the persons life. Almost 50 per centum of all worlds? malignant neoplastic disease cells contain a p53 mutant. An congenital defect in the p53 cistron occurs in households with the rare upset called? Li-Fraumen-Syndrom? , which causes an familial susceptibleness of early malignant neoplastic diseases, including chest malignant neoplastic disease ( Benjamin ) . Since p53 is so of import for normal cell growing in human research workers are go oning to look for ways to name, prevent and dainty malignant neoplastic disease associated with p53 ( American Cancer Society ) . It is know that BRCA1 and BRCA2 are tumour suppresser cistrons, which map to forestall phase of tumour development. Mutants in these cistrons merely appear in a few familial tumours, and are seldom in malignant neoplastic diseases or in normal tissues. The trial called? bracanalysis? , can observe those familial defects in a adult females with a strong household history of chest malignant neoplastic disease. The trial consists of a individual blood trial. This trial does non name malignant neoplastic disease nor will it foretell if or when malignant neoplastic disease will develop. The bracanalysis looks for a specific mutant on the cistrons BRCA1 and BRCA2. Women with a household history of chest malignant neoplastic disease are more likely to seek familial proving if they believe in the benefits. ? The trial cost between four hundred dollars and two thousand four hundred dollars depending on the type of trial needed, and takes about a hebdomad to obtain the consequences? ( Policy Statement of Genetic Testing of Breast Cancer and Ovarian Cancer in Women ) . Everyone is eligible to take the bracanalysis trial, nevertheless, some should take it in history more that others. Harmonizing to the National Cancer Society any adult females who fall into any of this classs should take in history of taking the trial. *Any adult females who has a personal history of chest malignant neoplastic disease. *Any adult females who have/had two or more close relations with chest malignant neoplastic disease. *Any adult females who have/had a comparative with chest malignant neoplastic disease at an early age. *Any adult females who have/had a comparative with bilateral ( both sides ) chest malignant neoplastic disease *Any adult females who has a form of chest malignant neoplastic disease in more than one coevals of their household. Any adult female who takes the trial will be faced with plentifulness of hazards. Marin Penalist and oncologist and a chest specializer said, ? If you have the trial done it comes up with a positive, it becomes a catastrophe? you? ll neer acquire medical insurance again. ? ( qtd. in Jacobson ) . There are opportunities that after taking the trial the adult females may endure favoritism, from insures, such as wellness, life, and disablement and from employers. A adult female may besides endure from psychological hurt. Mildred Cho, Ph.D. , helper professor at Penn? s centre for bioethics, said that? one of the grounds for this limited sum of information? ? ? is the trouble of acquiring informations about the public presentation of the trial detect late-onset conditions? ( qtd in Randolph 2 ) . Another thing Cho stated was that for this trial to come out accurate at that place will hold to be a batch of clip and research invested, and the development of this trial has non been around fo r that long. One of the Major hazard a adult females? s pickings is that is the consequences come out positive she will hold to populate with this for the remainder of her life. Taking this trial will besides provide that individual with benefits. The adult female has the opportunity of happening out if she will develop chest malignant neoplastic disease or non ( kelly 4 ) . For illustration, if a adult female has a household history of chest malignant neoplastic disease the most appropriate thing to make from halting malignant neoplastic disease to harm her is by taking both chests. Now with the bacanalysis trial the adult females have a opportunity to cognize if she should take her chest or non. The Cancer hazard and Assessment and Counseling Report stated that three hundred and twenty four adult females who had household history of chest malignant neoplastic disease decided to take their chests and merely 25 developed chest malignant neoplastic disease. At least 40 and as one hundred chest malignant neoplastic disease would hold been expected. Any adult females who takes the trial and gets positive will be obligated to go to guidance for at least six mont hs or one twelvemonth. Counseling that outlines the benefits of familial testing for chest malignant neoplastic disease may be an of import tool for forestalling the disease ( kelly 2 ) . Even in the absence of familial proving malignant neoplastic disease hazard and appraisal is recommended for persons with a household history of malignant neoplastic disease. Cancer hazard reding includes: ? Obtaining elaborate household, medical, and life manners ? Documenting cancer- related diagnosings ? Constructing and analysing household history ? Supplying hazard appraisal and guidance ? Discoursing options for early sensing and bar ? Discoursing hazard and benefits of cistron proving Today there is no remedy for chest malignant neoplastic disease, but the ability to make the right process will minimise the menaces breast malignant neoplastic disease had upon adult females. Today there are plentifulness of topographic points a adult female could seek aid and intervention. There are non any grounds why the chest malignant neoplastic disease should non be detected early. If every adult females follows up the process of BSE, takes the mammography yearly and takes in history that chest malignant neoplastic disease is a really serious disease, chest malignant neoplastic disease would non hold such a strong influence among Ame rican adult females today Familial Testing for Breast Cancer Breast Cancer touches each of our lives in someway. Almost everyone knows person who has been touched by it, and many of us live in fright of what it will make to us personally. Breast malignant neoplastic disease has been around of all time since I can retrieve ; it has affected my grandma and my female parent. Unfortunately my female parent was non able to contend this awful disease and died when I was merely 16. These were really difficult times for me, and of all time since so, my life has neer been the same. I neer knew how painful this disease could be for the person every bit good as for the household, by conveying agony and opening lesions that neer heal. Harmonizing to the National Women Health Information Center, chest malignant neoplastic disease is the most normally diagnosed malignant neoplastic disease and the 2nd prima cause of malignant neoplastic disease decease in American adult females today. The Health Technology Advisory Committee, estimates that there will be ap proximately 175,000 new instances of invasive chest malignant neoplastic disease this twelvemonth among adult females in the United States and there will be an norm of 43,300 adult females deceasing from this disease yearly. Breast malignant neoplastic disease is the most common type of malignant neoplastic disease among adult females, with about one in nine adult females developing the disease in her life-time ( National Cancer society. ) Although chest malignant neoplastic disease is known to impact adult females, it besides can be every bit lay waste toing to work forces. Male chest malignant neoplastic disease histories for one per centum of all diagnosed malignant neoplastic disease. Breast Cancer is disease in which cancerous cells are found in the tissues of the chest. These cancerous cells continue to turn and finally organize into lumps known as a tumour. A tumour is a mass of new tissue growing that is unresponsive to normal controls of the organisation influence of next tissues ; has no utile physiological map ( Lexicon Universal Encyclopedia 19:330 ) . The are two sort of tumours found in a adult females chest ; a benign and a malignant tumour. A benign tumour by and large grows easy and does non distribute to any portion of the organic structure. On the other manus, a malignant tumour is really unsafe. This tumour kills unless treated, because of its invasive and metastatic features. Every adult female is at hazard of obtaining Breast Cancer, nevertheless, some are at higher hazard than others. Simply being a adult female is the chief hazard factor for developing chest malignant neoplastic disease. Breast malignant neoplastic disease can impact work forces, but this disease is about one hundred times more common among adult females. A adult females? s hazard of developing chest malignant neoplastic disease increases with age. About 77 per centum of adult females with chest malignant neoplastic disease are over age 50 at the clip of diagnosing. Womans aged between 20 and 39 history for merely zero three per centum of chest malignant neoplastic disease instances ( TNCI ) . A chart from the National Cancer Institute illustrated that a adult female by that age of 30 is one out of two thousand five 100s and 20 at hazard of obtaining chest malignant neoplastic disease. The chart besides illustrated that a adult female by the age of eight her hazards of obtaining chest malignant neoplastic disease addition by one out of 10. Research has showed that those adult females, who have a personal history of chest malignant neoplastic disease, are five to six times at greater hazard of acquiring the disease than those who don? Ts have a personal history ( Hirshuat 67 ) . Womans who got their menses before the age of 12 are besides at higher hazard of developing malignant neoplastic disease than those who got their menses after the age of 15. Louise Brinton, Ph.D. , head of the Environmental Studies Section at the National Cancer Institute stated that, ? Many misss who get their periods at an early age tend to be corpulent, which is a separate hazard factor later in life. ? ( qtd. Women Weigh the Pros and Cons of Genetic Testing for Breast Cancer ) . The mean age of climacteric in the United States is about 55. Womans who enter climacteric after the mean age are at twice the hazard of developing chest malignant neoplastic disease so adult females who enter climacteric before ago of 55. Never holding a kid or holding the first kid after age of 35 would besides increase their hazard of developing chest malignant neoplastic disease. Research workers from the National Cancer Society have stated that the usage of intoxicant is clearly proven to increasing hazard of developing chest malignant neoplastic disease. Compared with abstainers, adult females who consume one alcoholic drink a twenty-four hours have a really little addition in hazard. Those who have two to five drinks daily are about one and a half times higher in hazard than adult females who do non imbibe intoxicant. There are many ways to observe chest malignant neoplastic disease. The earliest chest malignant neoplastic diseases found the better the opportunities for successful intervention. Every adult female should follow these guidelines whether they have a household history of chest malignant neoplastic disease or non. Mammography is an X ray of the chest. This is used to happen the disease in adult females who have symptoms or do non hold any chest jobs. Every adult female who falls between the ages of 40 and 90 should take this trial yearly. The mammogram should be between 25 dollars and two hundred and 25 dollars, there are assorted organisations and adult females support groups across the state who provide referrals to low-cost or free mammography services. Clinical Breast Examinations is another manner to observe chest malignant neoplastic disease. In this test, the wellness professional examines the adult females? s chest for any alterations in form or size and so gently fells the che st. This test should be practiced every three old ages for adult females who are in the ages between 20 and thirty-nine. Another easy and cheap manner to observe chest malignant neoplastic disease is by making the chest introspection ( Library General Health Encyclopedia ) . BSE consist of analyzing the chest every month or a hebdomad after every menses period. All this methods are utile for observing chest malignant neoplastic disease before it becomes a tumour. Breakthrough in familial research have identified two cistrons which will convey hope to many adult females by conveying them consequences of life economy, early sensing and intervention. However, this trial has hazards and benefits. The thought that cistrons play a function in 1s hazard of obtaining chest malignant neoplastic disease is terrorizing. However, in fact, genetic sciences is one of the most exciting and advanced countries of research in chest malignant neoplastic disease today. This recent find brings hope to many adult females. Approximately 5-10 % of chest malignant neoplastic disease instances are caused by a known familial familial alteration ( Breast Cancer Genes: The BRCA1 and BRCA2 ) . The first cistron to be identified was the BRCA1, Breast Cancer Gene 1. BRCA1 was discovered in 1994 after 4 old ages of research by a squad lead by Dr. Mark Skolnick, Ph.D. , a genetic sciences and professor of the University of Utah Medical Center and Dr. Roger Wiseman of NIH ( Benjamin ) . The cistron is located in the long arm of the chromosome 17, one of the 23 braces of chromosomes found in the human cells ( BRCA1 Sequence Analysis ) . Sean V. Tavtigian stated in the article BRCA 1 cistrons and its Protein Products, that any adult females who has a household history of chest malignant neoplastic disease, has a even opportunity of inheriting a flowed transcript from either parent? ( qdt. BRCA1 Gena 18 ) . Dr. Mark Skolnick noted that the cistron? BRCA 1 is over 10 times larger than the mean cistron and could be prone to many types of mutant along its? span? ( qtd. in Baron-Faust 10 ) . A adult female who inherits a faulty transcript of BRCA 1 from her female parent or male parent besides has a normal transcript of the BRCA1 on most of the instances. Equally long as one normal transcript is present, her chest malignant neoplastic disease cells function usually. However, at some clip during her life, she is really likely to endure a mutant to the staying normal cistron transcript in one or more breast cells. The rate for these cells to develop into chest malignant neoplastic disease is highly high. Harmonizing to the Policy Statement of Genetic Testing for Breast Cancer, every bit many as 90 per centum of these adult females will develop it than a adult females with? normal? cistrons. A 2nd of import cistron act uponing chest malignant neoplastic disease today is BRCA2, chest malignant neoplastic disease cistron 2. This cistron was identified in 1995 by Dr. Douglas Easton of London? s Institute of Cancer Research ( Benjamin ) . The cistron is located in the long arm of chromosome 13. Another major familial defect associated with BRAC2 a tumour suppresser cistron called p53 located on the short arm of chromosome 17 ( Baron-Faust 58 ) . The? P? is used as an abbreviation for stating that is in the smallest portion of the chromosome 17. Another jobs in the cistron p53 will interfere with the production of a protein is what keeps that cells growing under control. Defects in p53 are believed to be among the most common familial defect in chest malignant neoplastic disease. A individual can be born with a faulty cistron or the cistron can go damaged thought the persons life. Almost 50 per centum of all worlds? malignant neoplastic disease cells contain a p53 mutant. An congenital defect in the p53 cistron occurs in households with the rare upset called? Li-Fraumen-Syndrom? , which causes an familial susceptibleness of early malignant neoplastic diseases, including chest malignant neoplastic disease ( Benjamin ) . Since p53 is so of import for normal cell growing in human research workers are go oning to look for ways to name, prevent and dainty malignant neoplastic disease associated with p53 ( American Cancer Society ) . It is know that BRCA1 and BRCA2 are tumour suppresser cistrons, which map to forestall phase of tumour development. Mutants in these cistrons merely appear in a few familial tumours, and are seldom in malignant neoplastic diseases or in normal tissues. The trial called? bracanalysis? , can observe those familial defects in a adult females with a strong household history of chest malignant neoplastic disease. The trial consists of a individual blood trial. This trial does non name malignant neoplastic disease nor will it foretell if or when malignant neoplastic disease will develop. The bracanalysis looks for a specific mutant on the cistrons BRCA1 and BRCA2. Women with a household history of chest malignant neoplastic disease are more likely to seek familial proving if they believe in the benefits. ? The trial cost between four hundred dollars and two thousand four hundred dollars depending on the type of trial needed, and takes about a hebdomad to obtain the consequences? ( Policy Statement of Genetic Testing of Breast Cancer and Ovarian Cancer in Women ) . Everyone is eligible to take the bracanalysis trial, nevertheless, some should take it in history more that others. Harmonizing to the National Cancer Society any adult females who fall into any of this classs should take in history of taking the trial. *Any adult females who has a personal history of chest malignant neoplastic disease. *Any adult females who have/had two or more close relations with chest malignant neoplastic disease. *Any adult females who have/had a comparative with chest malignant neoplastic disease at an early age. *Any adult females who have/had a comparative with bilateral ( both sides ) chest malignant neoplastic disease *Any adult females who has a form of chest malignant neoplastic disease in more than one coevals of their household. Any adult female who takes the trial will be faced with plentifulness of hazards. Marin Penalist and oncologist and a chest specializer said, ? If you have the trial done it comes up with a positive, it becomes a catastrophe? you? ll neer acquire medical insurance again. ? ( qtd. in Jacobson ) . There are opportunities that after taking the trial the adult females may endure favoritism, from insures, such as wellness, life, and disablement and from employers. A adult female may besides endure from psychological hurt. Mildred Cho, Ph.D. , helper professor at Penn? s centre for bioethics, said that? one of the grounds for this limited sum of information? ? ? is the trouble of acquiring informations about the public presentation of the trial detect late-onset conditions? ( qtd in Randolph 2 ) . Another thing Cho stated was that for this trial to come out accurate at that place will hold to be a batch of clip and research invested, and the development of this trial has non been around fo r that long. One of the Major hazard a adult females? s pickings is that is the consequences come out positive she will hold to populate with this for the remainder of her life. Taking this trial will besides provide that individual with benefits. The adult female has the opportunity of happening out if she will develop chest malignant neoplastic disease or non ( kelly 4 ) . For illustration, if a adult female has a household history of chest malignant neoplastic disease the most appropriate thing to make from halting malignant neoplastic disease to harm her is by taking both chests. Now with the bacanalysis trial the adult females have a opportunity to cognize if she should take her chest or non. The Cancer hazard and Assessment and Counseling Report stated that three hundred and twenty four adult females who had household history of chest malignant neoplastic disease decided to take their chests and merely 25 developed chest malignant neoplastic disease. At least 40 and as one hundred chest malignant neoplastic disease would hold been expected. Any adult females who takes the trial and gets positive will be obligated to go to guidance for at least six mont hs or one twelvemonth. Counseling that outlines the benefits of familial testing for chest malignant neoplastic disease may be an of import tool for forestalling the disease ( kelly 2 ) . Even in the absence of familial proving malignant neoplastic disease hazard and appraisal is recommended for persons with a household history of malignant neoplastic disease. Cancer hazard reding includes: ? Obtaining elaborate household, medical, and life manners ? Documenting cancer- related diagnosings ? Constructing and analysing household history ? Supplying hazard appraisal and guidance ? Discoursing options for early sensing and bar ? Discoursing hazard and benefits of cistron proving Today there is no remedy for chest malignant neoplastic disease, but the ability to make the right process will minimise the menaces breast malignant neoplastic disease had upon adult females. Today there are plentifulness of topographic points a adult female could seek aid and intervention. There are non any grounds why the chest malignant neoplastic disease should non be detected early. If every adult females follows up the process of BSE, takes the mammography yearly and takes in history that chest malignant neoplastic disease is a really serious disease, chest malignant neoplastic disease would non hold such a strong influence among American adult females today